林治华

个人简介

林治华,教授,博士生导师。重庆市免疫协会副理事长,重庆市生物医学工程学会理事,重庆市十二五重点学科药学学科带头人,重庆市有突出贡献的中青年专家,重庆市科技创新领军人才,教育部新世纪优秀人才。1988.09-1992.07,获得成都科技大学无机化工学士学位;1997.09-2000.07,获得重庆大学物理化学专业硕士学位;2000.09-2003.07,获得中国人民解放军第三军医大学免疫学专业博士学位。2001.12-至今,重庆理工大学药学与生物工程学院教师。在《RSCadvances》、《Peptides》、《化学学报》等国内外重要学术期刊上发表研究论文90余篇,其中被SCI收录50余篇,发表论文共被他人引用1000余次;授权专利5件;获得2009年度中华医学科技奖一等奖1项(排第8);获得2008年度高等学校科学研究优秀成果奖(科学技术)自然科学二等奖1项(排第1);获得2008年度重庆市科技进步二等奖1项(排第4)。

研究领域

(1)免疫信息学与疫苗设计

(2)基于重要靶点的药物高通量筛选

承担的主要项目

[1] HPV16型E7抗原CTL表位模拟肽抗HPV感染的实验研究,国家自然科学基金面上项目,2012.01-2015.12,58 万,主持。

[2]基于CTL免疫识别的结构信息表达及构效关系建模,国家自然科学基金面上项目,2009.01-2011.12,30万,主持。

[3]高效树突状细胞靶向DNA疫苗激发抗宫颈癌免疫应答的实验研究,国家自然科学基金面上项目,2006.01-2008.12,27万,主持。

[4]基于非蛋白氨基酸设计合成CTL模拟表位及免疫学效应的研究,国家自然科学基金面上项目,2005.01-2007.12,24万,主持。

[5]核苷类似物干预下HBV准种全长序列变异模式及其选择特性研究,国家自然科学基金重点项目,2009.01-2012.12,180万,参与。

[6]教育部新世纪优秀人才支持计划项目,2006-2009,50万,主持。

[7]重庆市高校创新团队“计算机辅助药物设计与化学生物学”,2010-2013,60万,主持。

[8]重庆市科技创新领军人才支持计划项目,2014-2016,45万,主持。

[9]介导金黄色葡萄球菌免疫逃逸的目标分子及作用机制,重庆市科委重点自然基金项目,2013-2015,20万,主持。

[10]一种具有抗HBV活性的抗爱滋病药物抗HBV作用机制的研究,重庆市科委重点自然基金项目,2016-2018,20万,主持。

代表性成果

论文

1. Juan Wang, Mao Shu, XiaorongWen, Yuanliang Wang, Yuanqiang Wang, Yong Hu and Zhihua Lin*. Discovery ofvascular endothelial growth factor receptor tyrosine kinase inhibitors byquantitative structure–activity relationships, molecular dynamics simulationand free energy calculation. RSC Advances. 2016, 6(42), 35402-35415.

2. Mao Shu, Xiaoli Zai, BeinaZhang, Rui Wang, Zhihua Lin*. Hypothyroidism Side Effect in Patients Treatedwith Sunitinib or Sorafenib: Clinical and Structural Analyses. PLOS ONE.2016, Jan 19;11(1):e0147048.

3. Wang Yuanqiang, ZhouPengpeng, Lin Yong, Shu Mao, Hu Yong, Xia Qingyou, Lin Zhihua*. QuantitativePrediction of Class I MHC/Epitope Binding Affinity Using QSAR Modeling Derivedfrom Amino Acid Structural Information. Comb Chem High Throughput Screen. 2015,18(1): 75-82.

4. Yu Rui, Wang Juan, Wang Rui,Lin Yong, Hu Yong, Wang Yuanqiang, Shu Mao, Lin Zhihua*. Combined pharmacophoremodeling, 3D-QSAR, homology modeling and docking studies on CYP11B1 inhibitors.Molecules. 2015 Jan 9;20(1):1014-30.

5. Xiurong Li, Mao Shu,Yuanqiang Wang, Rui Yu, Shuang Yao and Zhihua Lin*. 3D-QSAR Analysis on ATRProtein Kinase Inhibitors Using CoMFA and CoMSIA. Current Computer-Aided DrugDesign, 2014, 10(4), 327-334.

6. Yuanqiang Wang, Yong Lin,Mao Shu, Rui Wang, Yong Hu, Zhihua Lin*. Proteasomal cleavage site predictionof protein antigen using BP neural network based on a new set of amino aciddescriptor. Journal of molecular modeling, 2013,19(8):3045-3052.

7. Wenjuan Yang, Mao Shu, Yuanqiang Wang, Rui Wang, Yong Hu, Lingxin Meng,Zhihua Lin*. 3D-QSAR and docking studies of 3-Pyridine heterocyclic derivativesas potent PI3K/mTOR inhibitors. Journal of Molecular Structure, 2013, 1054:107-116.

8. Yongjun Ji, Mao Shu, yuangqiang Wang, Yong Hu, Yong Lin, zhihuaLin*. 3D-QSAR Studies of Azacycles CCR5 Antagonists Using CoMFA and TopomerCoMFA. Journal of molecular structure, 2013, 1045 (3): 35-41.

9. Shu Mao,Yu Rui, Zhang Yunru, WangJuan, Yang Li, Wang Li, Lin Zhihua*. Predicting the Activity ofAntimicrobial Peptides with Amino Acid Topological Information. Medicinal Chemistry,2013,9(1):32-44.

10. Xingyan Luo, Mao Shu, Yuanqiang Wang, Jin Liu, Wenjuan Yang andZhihua Lin *.3D-QSAR Studies of Dihydropyrazole and Dihydropyrrole Derivativesas Inhibitors of Human Mitotic Kinesin Eg5 Bas ed on Molecular Docking. Molecules,2012, 17(2), 2015-2029.

11. Yuanqiang Wang, Yuan Ding, Haixia Wen, Yong Lin,Yong Hu, Ya Zhang,Qingyou Xia and Zhihua Lin*.QSAR Modeling and Design of Cationic AntimicrobialPeptides Based on Structural Properties of A mino Acids. Combinatorial Chemistry& High Throughput Screening, 2012, 15(4), 347-353.

12. Yuanqing Wang, XiaomingCheng, Yong Lin, Haixia Wen, Li Wang, Qingyou Xia, Zhihua Lin*. QuantitativePrediction of TAP and MHC Class I Binding Peptides using QSAR Modeling based onAmino Acid Structural Information. Current Computer-Aided Drug Design, 2012, 8(1),50-54.

13. Shu M, Zhang YR, Tian FF,Yang L, Lin ZH[]. Molecular Docking and 3D-QSAR Research of BiphenylCarboxylic Acid MMP-3 Inhibitors. Chinese Journal of Structural Chemistry, 2012,31(3):443-451.

14. Mao Shu, Xiaoming Cheng, Yunru Zhang,Yuanqiang Wang, Yong Lin, LiWang, Zhihua Lin*.Predicting the activity of ACE inhibitory peptides with anovel mode of pseudo amino acid composition. Pro tein & Peptide Letters,2011,18(12):1233-1243.

15. Juan Wang, Xiao-Yu Wang, Mao Shu, Yuan-Qiang Wang, Yong Lin,Li Wang,Xiao-Ming Cheng, Zhi-Hua Lin*.QSAR Study on MHC Class I A alleles basedon the novel parameters of amino acids. Protein & Peptide Letters, 2011,18(9):956-963.

16. Jiankun Liu,Yuzhong Duan, Xiaoming Cheng, Xi Chen, Wei Xie, HaixiaLong, Zhihua Lin*, Bo Zhu. IL-17 is associated with poor prognosis and promotesangiogenesis via stimulating VEGF producti on of cancer cells in colorectalcarcinoma. Biochemical and Biophysical Research Communications. 2011,407(2):348-354.

17. Wang Yuanqiang, Zhang Heng,Lin Yong, Zhao Qi, Liu Hui, Zhang zhan, Lin Zhihua*. 3D-QSAR Studies onCaspase-mediated Apoptosis Activity of Phenolic analogues,Journal of Molecular Modelling, 2011,17(1):1-8.

18. Xiaoyu Wang, Juan Wang, YongLin , Yuan Ding ,Yuanqiang Wang, Xiaoming Cheng, Zhihua Lin*. QSAR study onangiotensin-converting enzyme inhibitor oligopeptides based on a novel set ofsequence information descriptors. Journal of Molecular Modelling, 2011,17(7):1599-1606.

19. Xie Rong-Kai, Long Hai-Xia,Cheng Xiao-Ming, Wang Yuan-Qiang, Lin Yong, Yang Ying, Zhu Bo, Lin Zhi-Hua*.Quantitative sequence-kinetics relationship in antigen-antiboby interactionkinetics based on a set of descriptors. Chemical Biology & Drug Design,2010,76(4):345-349.

20. Hai-Xia Long,Yuan-QiangWang, Yong Lin, and Zhi-Hua Lin*. QSAR Study on ACE Inhibitors by Using OSC-PLSAlgorithm. Journal of the Chinese Chemical Society, 2010, 57,417-422. 

21. Lin Zhi-Hua*, WangHuai-Liang, Zhu Bo, Wang Yuan-Qiang, Lin Yong,Wu Yu-Zhang. Estimation ofAffinity of HLA-A*0201 Restricted CTL Epitope Based on the SCORE Function. Protein& Peptide Letters,2009,16(5): 561-569.

22. Zhi-hua Lin*, Hai-xia Long,Zhu Bo, Yuan-qiang Wang, Yu-zhang Wu. New descriptors of amino acids and theirapplication to peptide QSAR study. Peptides,2008,29(10):1798-1805.

23. Yangdong He, Liwei Mao,Zhihua Lin, Yijing Deng, Yan Tang, Man Jiang,Wanling Li, Zhengcai Jia, JiangxueWang, Bing Ni, Yuzhang Wu. Identification of a common HLA-A*0201-restrictedepitope among SSX family members by mimicking altered peptide ligands strategy.Molecular Immunology, 2008,45:2455–2464.

24. Tang Y,Lin Z,Ni B,Wei J,Han J,Wang H,Wu Y. Analtered peptide ligand for naïve cytotoxic T lymphocyte epitope ofTRP-2(180-188) enhanced immunogenicity.Cancer Immunol Immunother.2007,56(3):319-29.

25. Ni B,Lin Z,Zhou L,Wang L,Jia Z,Zhou W,Diciommo DP,Zhao J,Bremner R,Wu Y. Induction ofP815 tumor immunity by DNA-based recombinant Semliki Forest virus or repliconDNA expressing the P1A gene.Cancer Detect Prev.2004,28(6):418-25.

26. Lin Zhihua*, Wu Yuzhang, ZhuBo, Ni Bing, Wang Li. Toward the Quantitative Prediction of T-Cell Epitopes:QSAR Studies on Peptides Having Affinity with the Class I MHC MolecularHLA-A*0201. Journal of Computational Biology, 2004,11(4): 683-694.

27. Lin Zhihua*, Liu Shushen, LiZhiliang. Molecular Modeling of Quantitative Structure Retention RelationshipStudies: Retention Behavior of Polychlorinated Dibenzofurans on GasChromatographic Stationary Phase of Varying Polarity by a Novel MolecularDistance Edge Vector. Journal of Chromatographic Science, 2002, 40(1):7~13.

28. 王娟,舒茂,林勇,胡勇,韩英子,林治华*. HPV16 E7抗原CTL表位拟肽设计及活性评价.生物化学与生物物理进展,2015, 42(12):1119~1127.

29. 林治华*,王槐亮,唐艳,吴玉章.计算机辅助筛选酪氨酸激酶相关蛋白TRP-2 CTL模拟表位.化学学报,2007,65(8):760~764.

30. 林治华*,胡勇,吴玉章. HLA-A*0201限制性CTL表位肽三维定量构效关系的研究.化学学报,2004,62(18):1693~1698.

专利:

1、林治华,舒茂,路亚阔,于蕊,孟令鑫。一种非蛋白氨基酸抗菌肽及其应用,(中国专利),ZL 201310246635.5(2013)。

2、王远强,林治华,丁元,蔡家利,韩英子。一组动物源性阳离子抗菌肽及其应用。(中国专利),ZL201110414617.4(2011)

3、林治华,马正伟,许雪青,朱波,王锐。4-(环己基)-胺基喹唑啉类化合物的应用,(中国专利),ZL201110026959.9(2011)

4、朱波,林治华,王槐亮,龙海霞,程晓明,陈正堂。肿瘤抗原TRAG-3模拟表位肽及其应用,(中国专利)ZL200910104554.5

5、朱波,龙海霞,林治华,陈正堂。与MHC-Ⅰ类分子结合的鼠Ⅲ型肝炎病毒多肽表位及应用。(中国专利),ZL200910104132.8

获奖:

1、 林治华,吴玉章,朱波,唐燕,王莉,韩俊峰。蛋白质抗原表位结构特性与免疫学效应关系的研究,高等学校科学技术奖自然科学奖(教育部),二等奖,2008。

2、 朱波,陈正堂,吴玉章,林治华,谢启超,邹岚,程晓明,陈芳琳,段玉忠。非小细胞肺癌免疫治疗基础及临床应用研究,重庆市科技进步奖,二等奖,2008.

3、 吴玉章、倪兵、李晋涛、万瑛、王莉、朱波、许桂莲、林治华、牟芝蓉、陈永文、白云、宋建勋。蛋白质抗原的免疫识别、应答及调节,中华医学科技奖,一等奖,2009.窗体底端