刘建辉

个人简介

刘建辉,教授,硕士生导师。教育部新世纪优秀人才,重庆市科技创新领军人才,重庆色谱学会副理事长,2000.09– 2003.06获得大连理工大学生物化工专业博士学位;1997.09– 2000.06获重庆大学物理化学专业硕士学位;1993.09– 1997.06获重庆工商大学应用化学专业学士学位。在国内外重要刊物如BrainResearch, Neurochemistry International, Journal of Biochemistry, NeuroscienceLetter, CNS& Neurological Disorder-Drug Target,PLOS ONE等发表论文54篇,其中SCI收录45篇,发表论文共被他人引用1200余次;授权专利2件;编写著作或教材3部。获得2009年重庆市技术发明奖三等奖1项(排名第1)。

研究领域

分子药理学,化学生物学

承担的主要项目

[1]. Txnip在京尼平苷拮抗高糖诱导的胰腺β细胞损伤中的作用机制研究(81373459),国家自然科学基金面上项目,2014.1-2017.12,65万,主持。

[2]. 京尼平苷激活GLP-1受体的抗氧化作用机制研究(30600813),国家自然科学基金青年基金项目,2007.1-2009.12,23万,主持。

[3]. 京尼平苷诱导胰岛素分泌与GLP-1R的相关性研究(30973576)2010.01-2010.12,8万,主持。

[4]. GLP-1受体激动剂的药理学机制研究(NCET-07-0913),教育部新世纪优秀人才支持计划,2008.01-2010.12,60万,主持。

[5]. 京尼平苷药理学(CSTC,2014cqkjcxljr009),重庆科技创新领军人才支持计划,2015.01-2017.12,45万,主持。

[6]. 京尼平苷调节胰腺β细胞胰岛素分泌的分子机制(CSTC, 2012JJB10033),重庆市科委重点项目,2012.01-2014.12,20万,主持。

[7]. Klotho启动子激动剂的功能及作用机制研究(CSTC,2007AA5029),重庆市科技攻关重大项目,2007.01-2010.12,100万,主持人

[8]. 京尼平苷对胰腺β细胞氧化还原状态的调节及作用机制研究(CSTC,2015jcyjbx0064),重庆市科委重点项目,2015.01-2017.12,20万,主持。

[9]. 催化与功能有机分子优秀团队,重庆市教委,2013.01-2015.12,60万,主持。

代表性成果(*,Corresponding author)

(1) ZhangYL,Yin F*,Liu JH*, Liu ZX, Zidichouski J.Geniposide attenuates the phosphorylation of tau protein in cellular andAPP/PS1 transgenic model of Alzheimer’s disease.Chem Biol Drug Des2016; 87(3):409-18.

(2) GuoLX, Liu CY,Yin F*,Liu JH*. Possible role ofAMPK/SIRT1 signaling on energy balance in geniposide-treated INS-1 cells.MedicinalChemistry2016; 87(1):33-38

(3) ZhangYL,Liu JH*., Liu ZX,Yin F*.Geniposideattenuated insulin-deficiency-induced acceleration of β-amyloidosis in theAPP/PS1 transgenic model of Alzheimer’s disease.Neurochem Int2015;89:7-16.

(4) ZhangYL, Xia ZN,Liu JH*, Liu ZX,Yin F*.Cell signalingtransduction mechanisms by which geniposide regulates insulin-degrading enzymeexpression in primary cultured cortical neurons.CNS& NeurologicalDisorders-Drug Targets2015; 14(3):370-7.

(5) LiuJH*,Liu ZX, Zhang YL,Yin F*.Leptin signaling plays a critical roleon geniposide ameliorating the phosphorylation of tau in cellular and APP/PS1transgenic mice.Acta Biochi Biophy Sin2015; 47(12):1018-22.

(6) LiuJH*, Liu ZX, Zhang YL, Yin F. A novel antagonistic role of naturalcompound icariin on neurotoxicity of amyloid β peptide.Indian Journal MedRes2015; 142:190-195.

(7) ZhangYL, Yin F,Liu JH*. Geniposide Protects pancreatic INS-1E β cellsfrom hIAPP-induced cell damage: Potential involvement of insulin degradingenzyme.Cell Biol Int2015; 39(4):373-8.

(8) GuoLX,Liu JH*, Yin F, Gao X. Regulation of insulin secretion bygeniposide: Possible involvement of phosphatidylinositol 3-phosphate kinase.EurRev Med Pharmacol Sci2014; 18 (9): 1287-1294.

(9) LiuJH*,Guo LX, Yin F, Zhang YL, Liu ZX, Wang YW. Geniposide regulates glucose-stimulatedinsulin secretion possibly through controlling glucose metabolism in INS-1cells.Plos One2013; 8(10):e78315

(10)Liu JH,Zhang YL, Deng XH, Yin F*. Geniposide decreases the level of Aβ1-42inthe brain of streptozotocin-induced diabetic rats.Acta Biochim Biophy Sin2013;45(9):787-91.

(11)Yin F, Zhang YL,Guo LX, Kong SZ,Liu JH*. Geniposide regulates insulin-degradingenzyme expression to inhibit the cytotoxicity of Aβ1-42incortical neurons.CNS & Neurological Disorders-Drug Targets2012:11(8):1045-51.

(12)Liu JH*,Xiao H, Yin F, Guo LX, Gao X. Glucagon-like peptide 1 receptor plays anessential role in geniposide attenuating lipotoxicity-induced β-cell apoptosisToxicology in vitro2012; 26(7):1093-7.

(13)Guo LX, Xia ZN,LiuJH*.Glucagon-like peptide 1 receptor plays a critical role ingeniposide-regulated insulin secretion in INS-1 Cells.Acta Pharm Sin2012;33: 237-41

(14)Yin F,LiuJH*, Ji XH, Wang YW, Zidichouski J, Zhang JZ. Silibinin: A novelinhibitor of Aβ aggregation.Neurochem Int2011;58:399-403.

(15)Yin F,LiuJH*, Ji XH, Wang YW, Zidichouski J, Zhang JZ. Baicalin prevents theproduction of hydrogen peroxide and oxidative stress induced by Aβ aggregationin SH-SY5Y cells.Neurosci Lett2011; 492(2):76-9.

(16)Yin F,LiuJH*, Zheng XX, Guo LX, Xiao H. Geniposide induces the expression ofHO-1 via PI3K/Nrf2-signaling to enhance the antioxidant capacity in primaryhippocampal neurons.Biol Pharm Bull2010;33(11):1841-6.

(17)Kong SZ, QianBB,Liu JH,Fan MX, Chen G, Wang Y. Cyclothiazide induces seizurebehavior in freely moving rats.Brain Res.2010; 1355:207-213.

(18)Yin F,LiuJH*, Zheng XX, Guo LX. GLP-1 receptor plays a critical role ingeniposide regulating the expression of heme oxygenase-1 in PC12 cells.Acta Pharm Sin2010;31:540-5.

(19)YinF,Liu JH*,Ji X, Wang YW, Zidichouski J, Zhang JZ.Screening of inhibitors for β-amyloid (Aβ) and human islet amyloid polypeptide(IAPP) aggregation from Atlantic Canada plant extracts.Pharma Biol2010;48(Suppl1): 14

(20)Yin F,LiuJH*,Xiao H, Kong S Z. Geniposide prevents PC12 cells from peroxynitritevia MAP kinase signal pathway.J Health Sci.2010;56(2):195-99.

(21)LiuJH*,Yin F, Guo LX, Deng XH,Hu YH. Neuroprotection of geniposide against hydrogen peroxide induced PC12cells injury: Involvement of PI3 kinase signal pathway.Acta Pharm Sin2009;30(2):159-65.

(22)Guo LX,LiuJH*, Xia ZN. Geniposide inhibits CoCl2-induced PC12 cellsdeath via the mitochondria dependent pathway.Chin Med J2009;122:2886-92.

(23)Liu JH*,YinF, Jing JJ, Hu YH. Geniposide, a novel agonist for GLP-1 receptor, preventsPC12 cells from oxidative damage via MAP kinase pathway.Neurochem Int2007;51:361-9.

(24)Liu JH*, YinF, Zheng XX, Hu YH, Guo LX, Deng XH, Chen G, Jing JJ, Zhang H.Neurotrophicproperty of geniposide for inducing the neuronal differentiation of PC12 Cells.Int J Develop Neurosci2006;24(7): 419-24.

(25)Yin F, Deng XH,Jing JJ.Liu JH*.Effects of triethylene tetramine on theG-quadruplex structure in the human c-Myc promoter.J Biochem2007;141:669-74.

(26)Guo LX, Yin F,Jing JJ,Liu JH*. Triethylene tetraamine induces the senescenceof human breast MCF-7 cells.Biotech lett2008;30(1):47-53.

(27)Liu JH*,GuoLX, Yin F, Zheng XX, Chen G, Wang Y. Characterization and antitumor activityof triethylene tetramine, a novel telomerase inhibitor.Bimed Pharmcothera2008;62:480-5.

(28)Kong SZ,LiuJH,Ramage AG, and Wang Y. Cardiac vagal preganglionic neurones in theintermediate zone of the brainstem in anaesthetized cats.Exp physi2007;92(6):1023-8.

(29)Jiang B, Du J,LiuJH,Bao YM, An LJ. Catalpol attenuates the neurotoxicity induced byβ-amyloid1-42 in cortical neuron–glia cultures.Brain Res2008; 188:139-47.

(30)Bi J,Jiang B,Liu JH,Lei C,Zhang XL,An LJ. Protective effectsof catalpol against H2O2-induced oxidative stress in astrocytes primarycultures.Neurosci Lett.2008;442(3):224-7.