鲁秀敏

u个人简介

    鲁秀敏,博士,教授,硕士生导师。重庆市学术技术带头人后备人选,重庆市遗传学会常务理事。1993.09-1997.07,获得西南大学遗传育种专业学士学位;2000.09-2003.07,获得西南大学生物化学与分子生物学专业硕士学位;2005.09-2008.07,获得第三军医大学外科学专业博士学位。2003.07-至今,重庆理工大学药学与生物工程学院教师。在国内外重要刊物如Hum Mol GenetBiomaterialsMol NeurobiolCurr Pharm DesignBiomed Pharmacother等发表论文63篇,发表论文共被他人引用380余次;授权发明专利2件。2018年指导硕士研究生获得重庆市研究生科研创新项目1项;指导毕业研究生获得2017年重庆市优秀硕士论文1篇。

u研究领域

基因工程药物与天然药物,神经创伤与修复  

u承担的主要项目

[1]纳米金介导的GMCSF-NgR-PirB双靶向融合核酸疫苗的制备及其对损伤脊髓的免疫治疗作用与机制研究,国家自然科学基金面上项目,2018.1-2019.1225万,主持。

[2]靶向复合Nogo核酸疫苗的制备及其对损伤脊髓的免疫治疗研究,国家自然科学基金青年科学基金项目,2012.1-2014.1222万,主持。

[3]Nogo-APTSD大鼠海马突触改变及靶向免疫治疗中的作用与机制研究,国家自然科学基金面上项目,2017.1-2020.1210万,合作单位负责人

[4]双靶向NgR-PirB融合核酸疫苗的制备及其对损伤脊髓的免疫治疗作用研究,国家重点实验室课题,2017.5-2019.55万,主持。

[5]Nogo-66核酸疫苗接种对脊髓损伤的修复作用重庆市教委科学技术研究项目2010.1-2011.122万,主持。

[6]NTFs促进周围神经损伤修复分子机制的初步研究,国家重点实验室课题,2006.7-2007.125万,主持。

[7]雪旺细胞NF-kBNTFs促神经损伤修复中的作用,重庆市自然科学基金计划项目,2004.4-2006.42万,主持。

u代表性成果

[1]Wang YT, Lu XM (Corresponding author), Zhu F, Huang P, Yu Y, Long ZY, Wu YM. Ameliorative effects of p75NTR-ED-Fcon axonal regeneration and functional recovery in spinal cord-injured rats. Mol Neurobiol, 2015,52(3):1821-1834.

[2]Lu XM, Wei JX, Xiao L, Shu YH, Wang YT. Experimental and clinical advances in immunotherapy strategies for spinal cord injury target on MAIs and their receptors. Curr Pharm Design, 2016, 22(6): 728-737.

[3]Lu X, Su N, Yang J, Huang W, Li C, Zhao L, He Q, Du X, Shen Y, Chen L. Fibroblast growth factor receptor 1 regulates the differentiation and activation of osteoclasts through Erk1/2 pathway. Biochem Biophys Res Commun, 2009, 390 (3): 494-499.

[4]Huang J, Xiao L, Wei JX, Shu YH, Fang SQ, Wang YT, Lu XM (Corresponding author). Protective effect of arctigenin on ethanol-induced neurotoxicity in PC12 cells. Mol Med Rep, 2017, 15(4): 2235-2240.

[5]Fang SQ, Wang YT, Wei JX, Shu YH, Xiao L, Lu XM (Corresponding author). Beneficial effects of chlorogenic acid on alcohol-induced damage in PC12 cells. Biomed Pharmacother, 2016, 79:254-262.

[6]Shu YH, Lu XM (Co-first author), Wei JX, Xiao L, Wang YT. Update on the role of p75NTR in neurological disorders: A novel therapeutic target. Biomed Pharmacother, 2015, 76: 17-23.

[7]Wang YT, Lu XM (Corresponding author), Chen KT, Shu YH, Qiu CH. Immunotherapy strategies for spinal cord injury. Curr Pharm Biotechnol, 2015, 16(6): 492-505.

[8]Liu YJ, Zhou CY, Qiu CH, Lu XM (Corresponding author), Wang YT. Chlorogenic acid induced-apoptosis and inhibition of proliferation in human acute promyelocytic leukemia HL-60 cells. Mol Med Rep, 2013, 8 (4): 1106-1110.

[9]Lu XM, Shu YH, Qiu CH, Chen KT, Wang YT. Protective effects and anti-apoptotic role of nerve growth factor on spinal cord neurons in sciatic nerve-injured rats. Neurol Res, 2014, 36(9): 814-823.

[10]Wang YT, Lu XM (Corresponding author), Shu YH, Xiao L, Chen KT. Selection of human p75NTR tag SNPs andits biological significance for clinicalassociation studies. Biomed Mater Eng, 2014, 24 (6):3833-3839.

[11]Wang YT, Lu XM (Co-first author), Zhu F, Zhao M. The preparation of gold nanoparticles andevaluation of their immunological functioneffects on rats. Biomed Mater Eng, 2014, 24 (1): 885-892.

u联系方式

电话:13272641210E-mailluxm@cqut.edu.cn