殷菲

个人简介

殷菲,教授,硕士生导师。重庆市杰出青年基金获得者。2002.03–2005.06获得大连理工大学应用化学专业博士学位;1999.09– 2002.01获重庆大学物理化学专业硕士学位;1993.09– 1997.06获重庆大学精细化工专业学士学位。在国内外重要刊物如CNS&Neurological Disorder- Drug Target,PLOS ONE,Neurochemistry International, Neuroscience Letter,Journal of Biochemistry等发表论文38篇,其中SCI收录35篇,发表论文共被他人引用1000余次。

研究领域

化学生物学,分子药理学

承担的主要项目

[1]. 京尼平苷皮层神经元中调节胰岛素降解酶基因表达调控的分子机制(81173063),国家自然科学基金,202.01-2015.12年, 56万,主持。

[2]. 京尼平苷对海马神经元中Nrf2功能的调节机制及信号转导途径研究(30701020),国家自然科学基金,2008.01-2010.12年, 24万,主持。

[3]. 京尼平苷对神经元葡萄糖吸收和代谢的调节剂作用机制研究(2014jcyjjq10003),重庆市杰出青年基金, 2015.01-2017.12年,60万,主持。

[4]. 代谢性疾病药物药理,重庆市教委优秀创新团队,2016.09-2019.09,60万,主持。

[5]. 抗肿瘤药物增敏剂----三乙烯四胺的应用研究(CSTC,2008AC5028),重庆市科技攻关项目,2008.01-2010.12年, 15万,主持。

[6]. 京尼平苷激活胰高血糖素样肽1受体调节胰岛素降解酶基因表达的分子机制研究(211148),教育部重点基础项目,2011.01-2013.12, 10万,主持。

[7]. 京尼平苷调节Aβ代谢的分子机制,教育部回国人员科研启动基金,2012-2014年, 3万,主持。

[8]. 京尼平苷调节糖尿病动物脑内β淀粉样蛋白代谢的分子机制研究(CSTC2013jjb10032),重庆市科技计划重点项目,2013-2014年, 30万,主持。

代表性成果(*,Corresponding author)

1. ZhangYL,Yin F*, Liu JH, Liu ZX, Zidichouski J. Geniposide attenuatesthe phosphorylation of tau protein in cellular and APP/PS1 transgenic model ofAlzheimer’s disease.Chem Biol Drug Des2016; 87(3):409-18.

2. GuoLX, Liu CY,Yin F*, Liu JH. Possible role of AMPK/SIRT1 signalingon energy balance in geniposide-treated INS-1 cells.Medicinal Chemistry2016; 87(1):33-38

3. ZhangYL, Liu JH, Liu ZX,Yin F*.Geniposide attenuatedinsulin-deficiency-induced acceleration of β-amyloidosis in the APP/PS1transgenic model of Alzheimer’s disease.Neurochem Int2015; 89:7-16.

4. ZhangYL, Xia ZN, Liu JH, Liu ZX,Yin F*. Cell signaling transductionmechanisms by which geniposide regulates insulin-degrading enzyme expression inprimary cultured cortical neurons.CNS & Neurological Disorders-DrugTargets2015; 14(3):370-7.

5. LiuJH, Liu ZX, Zhang YL,Yin F*. Leptin signaling plays a criticalrole on geniposide ameliorating the phosphorylation of tau in cellular andAPP/PS1 transgenic mice.Acta Biochi Biophy Sin2015; 47(12):1018-22.(IF = 2.20)

6. LiuJH, Liu ZX, Zhang YL,Yin F*. Anovel antagonistic role of natural compound icariin on neurotoxicity of amyloidβ peptide.Indian Journal Med Res2015; 142:190-195

7. ZhangYL,YinF,Liu JH*. Geniposide Protects pancreatic INS-1E β cells fromhIAPP-induced cell damage: Potential involvement of insulin degrading enzyme.CellBiol Int2015; 39(4):373-8.

8. LiuJH, Zhang YL, Deng XH,Yin F*.Geniposidedecreases the level of Aβ1-42in the brain of streptozotocin- induced diabetic rats.Acta Biochim Biophy Sin2013;45(9): 787-91.

9. LiuJH, Guo LX,Yin F, Zhang YL, Liu ZX, Wang YW. GeniposideRegulates Glucose-Stimulated Insulin Secretion Possibly through ControllingGlucose Metabolism in INS-1 Cells.PLOS ONE2013; 8(10):e78315

10. Yin F,Zhang YL, Guo LX, Kong SZ, Liu JH. Geniposide regulates insulin-degradingenzyme expression to inhibit the cytotoxicity of Aβ1-42incortical neurons.CNS & Neurological Disorders-Drug Targets2012:11(8):1045-51.

11. GuoLX,Liu JH,Yin F, Gao X. Regulation of insulin secretionby geniposide: Possible involvement of phosphatidylinositol 3-phosphate kinase.Eur Rrev Med Pharmaco2014; 18 (9): 1287-1294.

12. LiuJH*, Xiao H,Yin F, Guo LX, Gao X. Glucagon-like peptide 1receptor plays an essential role in geniposide attenuating lipotoxicity-inducedβ-cell apoptosisToxicology in vitro2012; 26(7):1093-7.

13. Yin F, LiuJH, Ji XH, Wang YW, Zidichouski J, Zhang JZ. Silibinin: A novel inhibitor of Aβaggregation.Neurochem Int2011;58:399-403.

14. Yin F, LiuJH, Ji XH, Wang YW, Zidichouski J, Zhang JZ. Baicalin prevents the productionof hydrogen peroxide and oxidative stress induced by Aβ aggregation in SH-SY5Ycells.Neurosci Lett2011;492(2):76-9.

15. Yin F,LiuJH, Zheng XX, Guo LX, Xiao H. Geniposide indues the expression of HO-1 viaPI3K/Nrf2- signaling to enhance the antioxidant capacity in primary hippocampalneurons.Biol Pharm Bull2010;33(11):1841-6.

16. Yin F, LiuJH, Zheng XX, Guo LX. GLP-1 receptor plays a critical role in geniposideregulating the expression of heme oxygenase-1 in PC12 cells.Acta Pharm Sin2010.31:540-5.

17. Yin F, LiuJH,Xiao H, Kong S Z. Geniposide prevents PC12 cells fromperoxynitrite via MAP kinase signal pathway.J Health Sci.2010;56(2):195-199.

18. LiuJH,Yin F, Guo LX, Deng XH, Hu YH. Neuroprotection of geniposideagainst hydrogen peroxide induced PC12 cells injury: Involvement of PI3 kinasesignal pathway.Acta Pharm Sin2009;30(2): 159-65.

19. LiuJH,Yin F,Jing JJ, Hu YH. Geniposide, a novel agonist for GLP-1receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway.NeurochemInt2007;51: 361-9.

20. LiuJH,Yin F,Zheng XX, Hu YH, Guo LX, Deng XH, Chen G, Jing JJ,Zhang H.Neurotrophic property of geniposide for inducing theneuronal differentiation of PC12 Cells,Int J Develop Neurosci2006;24(7):419-24.

21. Yin F,Deng XH, Jing JJ. Liu JH*. Effects of triethylene tetraamine on theG-quadruplex structure in the human c-Myc promoter.J Biochem2007;141:669-74.

22. GuoLX,Yin F, Jing JJ, Liu JH*. Triethylene tetraamine induces thesenescence of human breast MCF-7 cells.Biotech lett2008;30(1):47-53.

23. LiuJH, Guo LX,Yin F, Zheng XX, Chen G, Wang Y. Characterization andantitumor activity of triethylene tetramine, a novel telomerase inhibitor.BimedPharmcothera2008;62: 480-5.

24. Yin F, LiuJH, Peng XJ.Triethylenetetraamine: A novel telomerase inhibitor.Bioorg Med ChemLett2003;13(22): 3923-6.

25. YinF,Liu JH, Peng XJ. Effect of triethylene tetraamine on the telomerase activityand proliferation in HeLa cells.Cell Biol Int2004;28(4):287-91.