殷菲

u个人简介

殷菲,博士,教授,硕士生导师。重庆市杰出青年基金获得者,重庆市巴渝学者,重庆市高校创新团队带头人1995.09-1999.07,获得重庆大学精细化工专业学士学位;1999.0-2002.01,获得重庆大学物理化学专业硕士学位;2002.03-2005.05,获得大连理工大学应用化学专业博士学位2005.05- 2009.07,重庆工商大学环境与生物工程学院教师;2009.08-2010.08,加拿大国家研究理事会营养与健康研究所访问学者;2010.08-2014.03重庆工商大学环境与生物工程学院教师;2014.04-2017.02,重庆理工大学药学与生物工程学院教师;2017.02-2018.01,美国北卡莱罗纳大学教堂山分校访问学者;2018.02-今,重庆理工大学药学与生物工程学院教师。近年来,主持或参与国家及省部级科研项目20余项;在国内外发表SCI研究论文30余篇,研究成果被包括发表在DiabetesPNASProgress in Neurobiology等高水平杂志上的文章多次引用,单篇引用超过100次的论文有3篇;相关研究结果申请及获得国际发明专利1项,中国发明专利1项;参与编写著作2部。

u研究领域

      代谢性疾病药物药理

u承担的主要项目

[1] 国家自然科学基金, 京尼平苷对海马神经元中Nrf2功能的调节机制及信号转导途径研究 (30701020), 2008.01 - 2010.12, 16万元, 主持

[2] 国家自然科学基金, 京尼平苷皮层神经元中调节胰岛素降解酶基因表达调控的分子机制 (81173063), 2012.01-2015.12, 56万元, 主持

[3] 重庆市科技创新团队, 代谢性疾病药物药理 (CXTDX201601031), 2016.07 - 2019.06, 60万元, 主持

[4] 重庆市杰出青年基金, 京尼平苷的脑保护机制(2014jcyjjq10003), 2014.12 - 2018.10, 60, 主持

[5] 重庆市科技计划重点项目, 京尼平苷调节胰腺b细胞葡萄糖转运体2内吞的分子机制研究, 2017.06 - 2020.09, 20万元, 主持

u代表性成果

      [1]论文:

1)Cui HQ, Deng MS, Zhang YL, Yin F*, Liu JH*. Geniposide increases unfolded protein response-mediating HRD1 expression to accelerate APP degradation in primary cortical neurons. Neurochem Res2018; 43(3): 669-80.

2)Liu CY, Hao YN, Yin F*, Zhang YL, Liu JH*. Geniposide accelerates proteasome degradation of Txnip to inhibit insulin secretion in pancreatic β cells. J Endocrinol Invest 2017; 40(5): 505-12.

3)Liu CY, Hao YN, Yin F*, Zhang YL, Liu JH*. Geniposide protects pancreatic β cells from high glucose-mediated injury by activation of AMP-activated protein kinase. Cell Biol Int 2017; 41(5): 544-54.

4)Liu ZX, ZhangYL, Liu JH*, Yin F*. Geniposide attenuates the level of Aβ1-42 via enhancing leptin signaling in cellular and APP/PS1 transgenic mice. Archives Pharm Res 2017; 40(5): 571-8.

5)Zhang YL, Yin F*, Liu JH*, Liu ZX. Geniposide attenuates the phosphorylation of tau protein in cellular and APP/PS1 transgenic model of Alzheimer’s disease. Chem Biol Drug Des 2016; 87(3): 409-18.

6)Zhang YL, Yin F*, Liu JH, Liu ZX, Guo LX, Xia ZN, Zidichouski J. Geniposide attenuated insulin-deficiency-induced acceleration of β-amyloidosis in the APP/PS1 transgenic model of Alzheimer’s disease. Neurochem Int 2015; 89: 7-16

7)Zhang YL, Xia ZN*, Liu JH, Liu ZX, Yin F*. Cell signaling transduction mechanisms by which geniposide regulates insulin-degrading enzyme expression in primary cultured cortical neurons. CNS & Neurological Disorders-Drug Targets 2015; 14(3): 370-7

8)Liu JH, Liu ZX, Zhang YL, Yin F*. Leptin signaling plays a critical role on geniposide ameliorating the phosphorylation of tau in cellular and APP/PS1 transgenic mice. Acta Biochi Biophy Sin 2015; 47(12): 1018-22.

9)Liu JH*, Liu ZX, Zhang YL, Yin F*. A novel antagonistic role of natural compound icariin on neurotoxicity of amyloid β peptide. Indian Journal Med Res 2015; 142: 190-5

10)Liu JH, Yin F*, ZhangYL, Liu ZX. Geniposide activated glucagons-like peptide 1 receptor to antagonize the cytotoxicity of Aβ1-42 and its molecular mechanisms. J Investigative Medicine 2013; 61(4): s11.

11)Liu JH, Zhang YL, Deng XH, Yin F*. Geniposide decreases the level of Aβ1-42 in the hippocampus of streptozotocin-induced diabetic rats. Acta Biochem Biophy Sin 2013; 45(9):787-91.

12)Yin F, Zhang YL, Guo LX, Kong SZ, Liu JH. Geniposide regulates insulin-degrading enzyme expression to inhibit the cytotoxicity of Aβ1-42 in cortical neurons. CNS& Neurological Disorders-Drug Targets 2012; 11(8):1045-51.

13)Yin F, Liu JH, Zheng XX, Guo LX, Xiao H. Geniposide indues the expression of HO-1 via PI3K/Nrf2-signaling to enhance the antioxidant capacity in primary hippocampal neurons. Biol Pharm Bull 2010; 33(11):1841-6.

14)Yin F, Liu JH, Zheng XX, Guo LX. GLP-1 receptor plays a critical role in geniposide regulating the expression of heme oxygenase-1 in PC12 cells. Acta Pharm Sin 2010; 31: 540-5.

15)Yin F, Liu JH, Xiao H, Kong S Z. Geniposide prevents PC12 cells from peroxynitrite via MAP kinase signal pathway. J Health Sci 2010; 56(2):195-9.

    [2]著作:

1)Liu JH, Yin F, et al. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Diesse. ELSEVIER 2015, 221-7.

2)Liu JH, Yin F, Zhang JZ, et al. Dietary Chinese Herbs. Springer 2013, Chapter 42, 51, 54

u联系方式

电话:62563182     E-mailfyin@cqut.edu.cn