u 个人简介  

李硕，副教授，硕士生导师。2002.09-2006.07，获得西南大学环境科学专业学士学位；2006.09-2009.07，获得西南大学有机化学专业硕士学位；2009.09-2012.07，获得四川大学有机化学专业博士学位。2012.07至今，重庆理工大学化学学院教师。近年来在《J. Mater. Chem. B.》，《Chem. Asia. J.》，《Dyes. Pigments.》，《J. Hazard. Mater》，《Mol. BioSyst.》，《RSC. Adv.》，《Sci. Chin. Chem.》，《Eur. J. Med. Chem.》，《Tetra. Lett.》，《J. Inorg. Biochem.》，《Bioorg & Med. Chem.》，《Bioorg & Med. Chem. Lett》，《Med. Chem. Comm》，《Int. J. Hydro. Eng》，《Fusion. Eng. Des》，《J. Nanosci. Nanotech.》，《J. Plant. Growth. Regul.》，《J. Chem. Res.》，《Prog. React. Kinet. Mec.》，《J. Chem. Pharm. Res.》，《化工学报》，《应用化学》，《高分子通报》，《材料进展》，《化学研究与应用》等杂志上以第一作者或通讯作者发表论文三十余篇，担任European Journal of Medicinal Chemistry，Future Medicial Chemistry, Letters in Drug Design & Discovery，Current Organic Chemistry, Current Topics in Medicinal Chemistry，Mini-Reviews in Medicinal Chemistry，Mini-Reviews in Organic Chemistry，Central Nervous System Agents in Medicinal Chemistry等杂志审稿人，申报发明专利3项，授权发明专利、新型实用专利3项。  

研究领域：有机功能材料；生物有机化学  

承担的主要项目  

[1] 具有高度仿病毒形态的靶向纳米凝胶基因递送系统的构建与性能研，重庆市基础与前沿研究计划项目，2018/07-2020/12，主持。  

[2] 氮杂冠醚聚合物作为仿病毒载体的研究，重庆市基础与前沿研究计划项目，2016/07-2019/07，主持。  

[3] 聚氮杂冠醚用于仿病毒载体的制备与性质研究，中国博士后基金特别资助，2016/04-2017/07，主持。  

[4] 多功能CXCR4靶向抗肿瘤转移树枝状分子载体系统研究，中国博士后面上项目，2014/09-2015/09，主持。  

[5] 可降解二元复合基因载体的构建及其性质研究，重庆市基础与前沿研究计划项目，2013/01-2016/12，主持。  

u 代表性成果  

[1] Wei-Wei Gao, Lavanya Gopala, Rammohan R. Yadav Bheemanaboina, Guo-Biao Zhang, Shuo Li*, Cheng-He Zhou*. Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically, drug-resistant Gram-negative Acinetobacter baumanii[J]. European Journal of Medicinal Chemistry, 2018, 146: 15~37.

[2] Jun-Rong Duan, Han-Bo Liu, Ponmani Jeyakkumar, Lavanya Gopala, Shuo Li*, Rong-Xia Geng, Cheng-He Zhou. Design, synthesis and biological evaluation ofnovel Schiff base-bridged tetrahydroprotoberberine triazoles as a new type of potential antimicrobial agents[J]. Medchemcomm, 2017, 8(5): 907~916.

[3] Ming-Qi Wang, Lie-Xiong Gao, Yi-Fan Yang, Xian-Ning Xiong, Zhao-Yi Zheng, Yuan Wu, Lu-Lu Ma, Shuo Li*. A triphenylamine derivative as a naked-eye and light-up fluorescent probe for G-quadruplex DNA[J]. Tetrahedron Letters, 2016, 57: 5042~5046.

[4] Lan Yu, Fang-zhen Li, Jiao-yi Wu, Jia-qing Xie, Shuo Li*. Development of the aza-crown ether metal complexes as articial hydrolase[J]. Journal of Inorganic Biochemistry, 2015, 154: 89~102.

[5] Shuo Li, Jia-Xuan Chen, Qing-Xiang Xiang, Li-Qun Zhang, Cheng-He Zhou, Jia-Qing Xie, Lan Yu, Fang-Zhen Li. The synthesis and activities of novel mononuclear or dinuclear cyclen complexes bearing azole pendants as antibacterial and antifungal agents[J]. European Journal of Medicinal Chemistry, 2014, 84(12): 677~686.

[6] Shuo Li, Yu Wang, Shan Wang, Ji Zhang, Shi-Fei Wu, Bo-Lin Wang, Wen Zhu, Xiao-Qi Yu. Biodegradable cyclen-based linear and cross-linked polymers as non-viral gene vectors[J]. Bioorganic & Medicinal Chemistry, 2012. 20(4): 1380~1387.

[7] Shuo Li, Yu Wang, Ji Zhang, Wei-Han Yang, Zhen-Hua Dai, Wen Zhu, Xiao-Qi Yu. Biodegradable cross-linked poly(amino alcohol esters) based on LMW PEI for gene delivery[J]. Molecular Biosystems, 2011. 7(4): 1254~1276.

联系方式  

电话：13983064764；E-mail：lishuo@cqut.edu.cn