个人简介
王锐，男，理学博士，副教授，硕士生导师，中心实验室主任。
Synlett, JOC,Research on Chemical Intermediates，Letters in Drug Design & Discovery，Drug Design, Development and Therapy评审专家;中国化学会会员
学习经历
2006/09-2009/06, 中国科学院学，成都生物研究所，药物化学，博士
2003/09-2006/06，四川大学，化学学院，生物有机化学，硕士
专业方向
1）药物合成方法学研究：羰基-烯烃复分解反应研究、杂环合成研究、不对称合成研究；
2）抗糖尿病药物、抗高血压药物、抗肿瘤药物合成；
3）高附加值药物中间体定制合成；
4）合成工艺改进技术攻关；
5) 药物杂质合成攻关；
6)结构鉴定服务。
科研成果
近年来发表SCI 收录学术论文多篇。主持及主研国家自然基金及重庆市科委、教委项目、企业横向项目多项。
[1] Jingyao Tan,Rui Wang, *Li Xu, Wenli Wu, Meijia Deng, Wanhong Yuan, Li Li, and Zhihua Lin. Synthesis of 2,3-disubstituted Benzofuran via HNTf2/TMSOTf Catalyzed Intermolecular Reaction of o-alkenyl phenols and Aldehydes.Adv. Synth. Catal.2023, 365, 983 – 989. (VIP文章，Q1，SCI Top期刊)
[2] Yi Chen; Di Liu; Rui Wang;* Li Xu; Jingyao Tan; Mao Shu; Lingfeng Tian; Yuan Jin; Xiaoke Zhang; Zhihua Lin;* Brønsted Acid-Catalyzed Carbonyl−Olefin Metathesis: Synthesis of Phenanthrenes via Phosphomolybdic Acid as a Catalyst.The Journal of Organic Chemistry,2022, 87(1): 351-362. (Q1，Top期刊，被引频次4)
[3]Rui Wang; Yi Chen; Mao Shu; Wenwen Zhao; Maoling Tao; Chao Du; Xiaoya Fu; Ao Li; Zhihua Lin;* AuCl3-Catalyzed Ring-Closing Carbonyl–Olefin Metathesis.Chemistry-A European Journal,2020, 26(9): 1941-1946. (Q1, Top期刊，Chemic Review综述，被引频次22)
[4] Xiao Xiao; Shuo Li; Xiaoxun Zhang; Jinjian Lu; Weiguang Wang; Shijia Zhou; Jingyao Zhang;Rui Wang;* Ao Li; HHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose deprived glucose-deprived breast cancer cells as a GRP78 down-regulator.Toxicology and Applied Pharmacology,2019, 373: 10-25.(SCI 3.8,被引频次7)
[5] Li Ao, Zhang Xiaoxun, Shu Mao, Wu Mingjun, Wang Jun, Zhang Jingyao,Wang Rui,* Li Peng,* Wang Yitao, Arctigenin suppresses renal interstitial fibrosis in a rat model of obstructive nephropathy.Phytomedicine2017, 30, 28-41. (SCI 3.5，被引频次41)
[6]Rui Wang,* Chun-hong An, Yang Li, Yue Zhao, Tao Wang, Ao Li* Direct Synthesis of 2-Arylbenzothiazoles from Benzothiazoles with Phenylglycine Derivatives Mediated by Cu(OTf)2/K2S2O8.Tetrahedron Letters2015, 56, 2077-2082. (SCI 2.6，被引频次7)
[7] Ao Li*, Jun Wang, Dan-Ping Zhu, Xiao-Xun Zhang, Ruo-Lin Pan,Rui Wang*. Arctigenin suppresses transforming growth factor-β1-induced expression of monocyte chemoattractant protein-1 and the subsequent epithelial-mesenchymal transition through reactive oxygen species-dependent ERK/NF-κB signaling pathway in renal tubular epithelial cells.Free radical research,2015, 49,1095-1113. (SCI 2.9，被引频次19)
[8]Rui Wang,* Yong-liang Ding, Hong Liu, Shu Peng, Jie Ren, Lei Li. Copper-catalyzed multicomponent reactions of 2-iodoanilines, benzylamines, and elemental sulfur toward 2-arylbenzothiazoles.Tetrahedron Letters2014, 55, 945-949. (SCI, 2.6，被引频次32)
[9]Rui Wang,*Hong Liu, Liang Yue, Xiao-ke Zhang, Qiu-yuan Tan, Ruo-lin Pan. Transition metal-free direct amination of benzoxazoles using formamides as nitrogen sources.Tetrahedron Letters2014, 55, 2233-2237. (SCI, 2.6,被引频次28)
[10]Rui Wang,* Wen-juan Yang, Liang Yue, Wei Pan, Hong-yao Zeng. DDQ-Promoted C–S Bond Formation: Synthesis of 2-Aminobenzothiazole Derivatives under Transition-Metal-, Ligand-, and Base-Free Conditions.Synlett.,2012, 11, 1643. (SCI, 2.7,被引频次24，有机化学门户网站评述http://www.organic-chemistry.org;Eur. J. Org. Chem.综述)
[11]Rui Wang,* Zhi Chen, Liang Yue, Wei Pan, Jun-Jie Zhao. Direct transition metal-free C–S bond formation: synthesis of 2-aminobenzothiazole derivatives via base-mediated approach.Tetrahedron Lett.,2012, 53, 4529. (SCI 2.6,被引频次21).
[12] Yang WJ, Shu M, Wang YQ, Wang R, Hu Y, Meng, LX, Lin, ZH. 3D-QSAR and docking studies of 3-Pyridine heterocyclic derivatives as potent PI3K/mTOR inhibitors. Journal of Molecular Structure 1054: 107-116, 2013. (SCI，被引频次15)
[13]Wang R, Huang TK, Shi L, Li BG. Lu XX. Heteropoly Acids Catalyzed Direct Mannich Reactions: Three-Component Synthesis of N-Protected β-Amino Ketones.Synlett.,2007, 2197–2200. (SCI 2.7,被引频次13)
[14]Wang R, Li BG, Huang TK, Shi L, Lu XX. NbCl5-Catalyzed One-pot Mannich-type Reaction: Three Component Synthesis of β–Amino Carbonyl Compounds.Tetrahedron Lett.,2007, 48, 2071–2073. (SCI 2.6,被引频次140)
[15]Wang R, Lu XX, Yu XQ, Shi L, Sun Y. Acid-Catalyzed Solvent-Free Synthesis of 2-Arylbenzimidazoles under Microwave Irradiation.Journal of Molecular Catalysis. A, Chemical,2007, 266, 198–201. (SCI 2.8,被引频次42)
[16]王锐;林治华;舒茂;安春红;李傲;胡勇;舒杭;陈乐园;杨涛;张兴;一类色原酮取代噻唑烷二酮化合物及其用于治疗糖尿病药物的应用, 2018-3-09,中国, 201610111974.6 (专利)
[17]王锐;胥秀英;刘红;张云玲;郑一敏;任杰;彭术;谢云;张洪兰;一种制备吗替麦考酚酯的方法, 2016-1-13,中国, ZL201310228373.X (专利)
