个人简历

张宁，博士/讲师

教育经历

2014年9月-2018年12月重庆大学药物化学博士

2011年9月-2014年6月中国药科大学药学硕士

2007年9月-2011年6月山东中医药大学制药工程学士

工作经历

2019年3月-2022年9月 陆军军医大学 第一附属医院（西南医院）博士后

2022年10月至今重庆理工大学药学与生物工程学院制药工程系专任教师

研究方向

1）抗肿瘤药物设计、合成和活性筛选；

2）炎症和氧化损伤相关疾病的诊疗一体化研究；

学术成绩

以第一作者和通讯作者发表SCI论文8篇，合作发表10余篇，申请发明专利2项。获国家自然科学基金、中国博士后科学基金、重庆市自然科学基金、重庆市博士后留渝资助和重庆理工大学科学启动基金等基金资助。

代表性科研项目：

1.国家自然科学基金，青年基金，82202448，硝基还原酶介导的级联靶向硫化氢供体对烧伤休克期脏器缺血再灌注损伤的治疗作用，资助金额30万元，主持（2023.1-2025.12）

2.中国博士后科学基金,面上项目, 2019M661976,级联靶向硫化氢供体递送系统对难愈性创面的修复与治疗,资助金额16万元,主持(2019.9-2022.6)。

3.重庆市自然科学基金，博士后面上项目, cstc2020jcyj-bshX0014,级联靶向ROS响应的荧光硫化氢供体用于心肌缺血再灌注损伤的治疗,资助金额10万元,主持（2020.9-2022.8）。

4.重庆市留渝博后人才发展科学基金，博士后留渝，资助金额15万元,主持（2023-2025）

5.重庆理工大学科研启动经费，2023ZDZ001,主持（2023.10-2025.10）

6.国际（地区）合作与交流合项目，响应性浓度梯度P311-石墨烯/胶原支架诱导创面修复及机制研究,（项目批准号：81920108022）参与。

7.国家重点研发计划：物理性因素调控组织干细胞促进创伤后组织原位再生修复的机制与新策略（项目批准号：2021YFA1101100），参与。

代表性论文

(1)Ning Zhang, Yifei Lu, Yong Huang, Qing Zhang, Jianglin Tan, Jianxiang Zhang*, Mengyun Yao*, Gaoxing Luo.* A novel fluorescent probe for real-time imaging of thionitrous acid under inflammatory and oxidative conditions. Redox Biology. 54, 2022,102372. IF: 11.799.

(2) Mengyun Yao, Yifei Lu, Lin Shi, Yong Huang, Qing Zhang, Jianglin Tan, Ping Hu,* Jianxiang Zhang,* Gaoxing Luo,*Ning Zhang.* A ROS-responsive, self-immolative and self-reporting hydrogen sulfide donor with multiple biological activities for the treatment of myocardial infarction. Bioactive Materials. 2022, 9,168-182. IF: 14.593

(3)Ning Zhang#, Ping Hu #, Yanfang Wang, Qing Tang, Qiang Zheng, Zhanlong Wang, Yun He *. A reactive oxygen species (ROS) activated hydrogen sulfide (H2S) donor with self-reporting fluorescence. ACS Sensors. 2020, 5(2): 319-326. IF: 7.711

(4)Ning Zhang#, Yun He #, Qing Tang, Yanfang Wang, Qiang Zheng, Ping Hu*. A mitochondrial targeting two-channel responsive fluorescence probe for imaging the superoxide radical anion in vitro and in vivo. Talanta. 2019, 194, 79-85. IF: 6.057

(5)Ning Zhang#, Zhimei Yu #, Xiaohong Yang, Ping Hu *, Yun He *. Synthesis of novel ringcontracted artemisinin dimers with potent anticancer activities. European Journal of Medicinal Chemistry. 2018, 150, 829-840. IF: 6.514

(6)Ning Zhang#, Zhimei Yu, Xiaohong Yang , Yan Zhou , Qing Tang , Ping Hu , Jia Wang , ShaoLin Zhang *, Ming-Wei Wang *, Yun He *. Difuran-substituted quinoxalines as a novel class of PI3Ka H1047R mutant inhibitors: Synthesis, biological evaluation and structure activity relationship. European Journal of Medicinal Chemistry. 2018, 157, 37-49. IF: 6.514

(7)Ning Zhang#, Zhimei Yu #, Xiaohong Yang, Yan Zhou, Jia Wang, Shao-Lin Zhang, *,Ming Wei Wang *, Yun He *. Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3Ka H1047R mutant inhibitors. European Journal of Medicinal Chemistry.

2018, 158, 707-719. IF: 6.514

(8) Na Qi #,Ning Zhang#, Srinivasa Rao Allu, Jiangsheng Gao, Jian Guo,* and Yun He*. Insertion of arynes into P−O bonds: One-Step simultaneous construction of C−P and C−O bonds. Organic Letters. 2016, 18, 6204-6207. IF: 6.005共同第一作者

(9) Zhang Qing; Shi Lin; He Hong; Liu Xingmou; Huang Yong; Xu Dan; Yao Mengyun;Zhang Ning; Guo Yicheng; Lu Yifei; Li Haisheng; Zhou Junyi; Tan Jianglin*; Xing Malcolm*; Luo Gaoxing*, Downregulating Scar Formation by Microneedle directly via mechanical communication pathway, ACS nano, 2022, 16, 7, 10163-10178

(10) Q. Tang, P. Hu, H. Peng,N Zhang, Q Zheng, Y. He, Near-Infrared Laser-Triggered, Self immolative Smart Polymersomes for in Vivo Cancer Therapy, Int. J. Nanome. 2020. 15, 137-149.

(11) Q. Zheng, Y. He, Q. Tang, Y. Wang,N. Zhang, J. Liu, Q. Liu, S. Zhao, P. Hu, An NIR-Guided Aggregative and Self-Immolative Nanosystem for Efficient Cancer Targeting and Combination Anticancer Therapy, Mol. Pharmaceutics, 2018, 15, 4985-4994

(12) D.Prabhakar Reddy,Ning Zhang, Zhimei Yu, Zhen Wang and Yun He. Total Synthesis of Kanamienamide. Journal of Organic Chemistry. 2017, 82 (20), 11262–11268

联系方式：zhangning88@cqut.edu.cn