个人简介

向钢，博士，讲师

教育经历

博士：2018.04-2022.08，上海交通大学，生物学专业

硕士：2014.09-2017.06，南京大学，制药工程专业

本科：2010.09-2014.06，湖北民族大学，化工与制药专业

工作经历

2022.12-至今，重庆理工大学药学与生物工程学院

2022.08-2022.10，百济神州，转化医学部，研究员

研究方向

肿瘤生物学，分子药理学

代表性科研项目

国家自然科学基金委员会，面上项目，32071298，“CCL5/CCR5”生物轴的生化分子基础和新型拮抗剂研究，2021-01-01至2024-12-31，58万元，在研，参与

代表性论文

1. Gang Xiang, Shuxuan Wang, Ling Chen, Mei Song, Xiaoxu Song, Huan Wang, Pengbo Zhou, Xiaojing Ma^⁎, and Jing Yu^⁎. UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer.Cell Death Dis. 2022 May 12;13(5):451.

2. Bingbing Wu, Mei Song, Qun Dong, Gang Xiang, Jing Li, Xiaojing Ma^⁎, Fang Wei^⁎. UBR5 promotes tumor immune evasion through enhancing IFN-γ-induced PDL1 transcription in triple negative breast cancer.Theranostics. 2022 Jul 4;12(11):5086-5102.

3. Jin Li¹, Wei Zhang¹, Jian Gao, Min Du, Huimin Li, Mengge Li, Hui Cong, Yuan Fang, Yiyi Liang, Dan Zhao, Gang Xiang, Xiaojing Ma, Ming Yao, Hong Tu^⁎, Yu Gan^⁎. E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1.Front Oncol.2021 May 11;11:693855.

4. Minmin Fan¹, Gang Xiang¹, Jingwei Chen, Jian Gao, Wenwen Xue, Yixuan Wang, Wuhao Li, Lin Zhou, Ruihua Jiao, Yan Shen^⁎, Qiang Xu^⁎. Libertellenone M, a diterpene derived from an endophytic fungus Phomopsis sp. S12, protects against DSS-induced colitis via inhibiting both nuclear translocation of NF-κB and NLRP3 infiammasome activation.Int Immunopharmacol.2020 Mar;80:106144.

5. Gang Xiang¹, Minmin Fan¹, Yuzhu Ma, Miao Wang, Jian Gao, Jingwei Chen, Xin Li, Wenwen Xue, Yixuan Wang, Huiyuan Gao,Yan Shen^⁎, Qiang Xu^⁎. Anti-inflammatory actions of Caesalpinin M2 in experimental colitis as a selective glucocoricoid receptor modulator.Biochem Pharmacol.2018 Apr;150:150-159.

6. Jian Gao, Minmin Fan, Shuang Peng, Minxia Zhang, Gang Xiang, XinLi, Wenjie Guo, Yang Sun, Xuefeng Wu, XudongWu, Guang Liang, Yan Shen^⁎, Qiang Xu^⁎. Small-molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer.Cell Death Dis.2017 Sep 14;8(9):e3049.

7. Jian Gao, Minmin Fan, Gang Xiang, Jujuan Wang, Xiong Zhang, Wenjie Guo, Xuefeng Wu, Yang Sun, Yanhong Gu, Huiming Ge, Renxiang Tan, Hongxia Qiu^⁎, Yan Shen^⁎, Qiang Xu^⁎. Diptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells.Cell Death Dis.2017 May 4;8(5):e2765.

8. Shanwei Mi, Gang Xiang, Daolu Yuwen, Jian Gao, Wenjie Guo, Xuefeng Wu,Xudong Wu, Yang Sun, Yongqian Su, Yan shen^⁎, Qiang Xu^⁎. Inhibition of autophagy by andrographolide resensitizes cisplatin-resistant non-small cell lung carcinoma cells via activation of the Akt/mTOR pathway.Toxicol Appl Pharmacol.2016 Nov 1;310:78-86.

授权发明专利

(1)徐强; 沈燕; 高健; 范旻旻; 向钢; 谭仁祥; 戈惠明; 吴雪丰; 白藜芦醇寡聚体Dip G在制备治疗急性髓性白血病的药物中的应用, 2019-04-05, 中国, CN201710170904.2.

联系方式

gangxiang@cqut.edu.cn