导 师 个 人 简 介

个人简介

副教授，硕士生导师

教育背景

2010/09 - 2015/06，重庆大学，化学工程与技术，博士，

工作简历：

2015年—至今 重庆理工大学药学与生物工程学院

教学与研究领域

承担制药工程专业本科教学，从事代谢性疾病药物药理相关研究

发表论文

Zhao WJ, Bian YP, Wang QH, Yin F, Yin L, Zhang YL, Liu JH, Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress, 2021，1-14.

Hao YN，Shen SL，Yin F，Zhang YL，Liu JH，Unfolded protein response is involved in geniposide-regulating glucose-stimulated insulin secretion in INS-1 cells, Cell Biochemistry and Function, 2019, 37(5)：368-376.

Cui HQ, Deng MS, Zhang YL, Yin F, Liu JH，Geniposide Increases Unfolded Protein Response-Mediating HRD1 Expression to Accelerate APP Degradation in Primary Cortical Neurons，Neurochemical Research, 2018, 43(3): 669-680.

Liu CY，Hao YN，Yin F，Zhang YL，Liu JH，Geniposide protects pancreatic beta cells from high glucose-mediated injury by activation of AMP-activated protein kinase，Cell Biology International, 2017, 41(5): 544-554.

Liu CY，Hao YN，Yin F，Zhang YL，Liu JH，Geniposide accelerates proteasome-degradation of Txnip to inhibit insulin secretion in pancreatic β cells，Journal of Endocrinological Investigation, 2017, 40(5): 505-512.

Gao D，Zhang YL，Yang FQ，Lin YX，Zhang QH，Xia ZN，In vitro Screening and Evaluation of 37 Traditional Chinese Medicines for Their Potential to Activate Peroxisome Proliferator‑activated Receptors‑γ，Pharmacognosy Magazine, 2016, 12(46): 120-127.

Hao YN，Liu CY，Yin F，Zhang YL，Liu JH，*5’-AMP-activated protein kinase plays an essential role ingeniposide-regulated glucose-stimulated insulin secretion in rat pancreaticINS-1 β cells Journal of Natural Medicines, 2016, 71(1): 123-130.

Gao D，Zhang YL，Yang FQ，Li F，Zhang QH，Xia ZN，The flower of Edgeworthia gardneri (wall.) Meisn. suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes，Journal of Ethnopharmacology，2016，191：379-386.

Zhang YL，Yin F，Liu JH，Liu ZX，Geniposide attenuates the phosphorylation of tau protein in cellular and APP/PS1 transgenic model of Alzheimer’s disease，Chemical Biology & Drug Design, 2016, 87: 409-418.

Gao D，Zhang YL，Xu P，Lin YX，Yang FQ，Liu JH，Zhu HW，Xia ZN，In vitro evaluation for PPARγ/β from the flower Edgeworthia gardneri(wall.)Meisn，Journal of Ethnopharmacology, 2015, 162: 14-19.Zhang YL，Xia ZN，Liu JH，Yin F，Cell signaling transduction mechanisms by which geniposide regulates insulin-degrading enzyme expression in primary cultured cortical neurons，CNS & Neurological Disorders-Drug Targets, 2015, 14(3): 370-377.

Zhang YL，Yin F，Liu JH，Liu ZX，Guo LX，Geniposide attenuated insulin-deficiency-induced acceleration of β-amyloidosis in the APP/PS1 transgenic model of Alzheimer’s disease，Neurochemistry International, 2015, 89: 7-16.

Liu JH，Liu ZX，Zhang YL，Yin F，A novel antagonistic role of natural compound icariin on neurotoxicity of amyloid β peptide，Indian Journal of Medical Research, 2015, 142(2): 190-195.

Zhang YL，Yin F，Liu JH，Wang YW，Geniposide protects pancreatic INS-1E β cells from hIAPP-induced cell，Cell Biology International, 2015, 39(4): 393-398.

教学及科研项目

Txnip和GnT-IVa与京尼平苷调节葡萄糖转运体内吞的相关性研究，国家自然科学青年基金项目，在研

AMPK和Itch介导的Txnip降解与京尼平苷调节胰腺β细胞氧化还原的相关性研究，重庆市自然基金项目，在研

奖励及荣誉

重庆理工大学“优秀班导师”，2020年

重庆市科学技术奖自然科学类二等奖（排名第四），《京尼平苷激活GLP-1受体的药理学机制研究》，2019年

重庆理工大学“就业工作先进个人”，2016年

联系方式： E-mail:lanzy2015@cqut.edu.cn